Pheromone-Induced Reproductive Inhibition in Young Female Peromyscus Leucopus1

Pheromone anosmia in a scarab beetle induced by in vivo inhibition of a pheromone-degrading enzyme.

Previous biochemical evidence suggests that a cytochrome P450 specific to male antennae of the pale-brown chafer, Phyllopertha diversa, has evolved as a pheromone-degrading enzyme. By using a bioinformatics approach, we have now cloned three P450 cDNAs: CYP4AW1, CYP4AW2, and CYP6AT1. RT-PCR indicated that CYP4AW2 is expressed in all tissues examined, that CYP6AT1 is antennae-rich, and that CYP4...

Antibiotic-induced inhibition of pheromone synthesis in a bark beetle.

Ingestion of diet containing streptomycin inhibited the conversion of myrcene, a host plant terpene, to the male-specific pheromones ipsenol and ipsdienol in 1ps paraconfusus. Synthesis of cis-verbenol, which is not a sex-specific pheromone, from the host plant terpene (-)-alpha-pinene and other metabolites from these two terpenes was not inhibited by the antibiotic.

Clozapine-induced cataract in a young female

A variety of systemic drugs including corticosteroids, amiodarone and antipsychotics have been known to cause cataract formation. Typical antipsychotics such as chlorpromazine have been reported to cause cataract formation in varying rates ranging from 22% to 80%. Cataract as an adverse effect resulting from the long term use of atypical antipsychotic has rarely been mentioned in literature, an...

The evolution of social and reproductive monogamy in Peromyscus, evidence from Peromyscus californicus (the California Mouse)

Inhibition of nicotine-induced behavioral tolerance by ascorbic acid in female mice

Administration of nicotine leads to incentive and behavioral tolerance in human and animals. Ascorbic acid administration inhibits some effects of nicotine. In the present study, the effects of ascorbic acid administration on the expression and development of nicotine-induced behavioral tolerance in female Swiss-Webster mice (20-25 g) was investigated. Animals were injected with nicotine (0.5 m...